Arizona State University
Arizona State University Physical Sciences-Oncology Center's (ASU PS-OC) foremost aim is to rigorously question the central tenets of cancer biology and to innovate paradigm shifting tactics that challenge the barriers of contemporary cancer research and treatments. These investigators hypothesize that cancer progression is linked to systematic physical differences in cells. Pioneering methods to survey these physical changes will be employed by this center, and theoretical evolutionary models will also be applied to establish the evolution of a metastatic cancer cell from a physical context. Moreover, the strategic partnership of distinguished scientists in cancer biology, clinical oncology and physics will lend to the technical advances introduced from this center. Along this line, these investigators have spearheaded single-cell tomography, which has isotropic 100 nm resolution and enables three-dimensional imaging of single cells. This center will use single-cell computerized tomography to characterize physical changes as potential cancer signatures.