National Cancer Institute
U.S. National Institute of Health www.cancer.gov National Cancer Institute
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FEATURED CENTER

 
Stanford University

Stanford University
University of California-Berkeley Physical Sciences-Oncology Center (UCB PS-OC) will determine how mechanobiology influences tumorigenesis in breast cancer. This center’s primary focus will be on the triple negative subtype of basal breast cancer, which lacks the estrogen, progesterone, and Her2/neu receptors. Patients with this more aggressive, triple negative subtype have fewer treatment options and an overall poor prognosis. These investigators hypothesize that the malignant phenotype is maintained by exchanges with its microenvironment and that reversion can occur if these pressures are normalized. This center will also examine how mechanical signals trigger genetic changes that induce tumorigenesis. Groundbreaking force probes and imaging techniques will gauge the forces within breast cancer model systems. The integration of these state-of-the-art tools in the physical, theoretical and biological sciences will cultivate models of various interactions of the model systems with their microenvironment. Furthermore, cellular plasticity and reversion research will be executed and could lead to potential therapeutics targeted to the cellular microenvironment.
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CENTERS

 
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Physical Science-Oncology Centers

The National Cancer Institute (NCI) has awarded cooperative agreements to 12 leading institutions to build a collaborative network of Physical Science-Oncology Centers (PS-OCs).

 

PHYSICAL SCIENCES-ONCOLOGY CENTERS

 
Arizona State University Arizona State University
Physical Sciences-Oncology Center
Arizona State University, Tempe, AZ

Principal Investigator: Paul Davies, Ph.D.
Scientific Investigator: William M. Grady, M.D.
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Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigator: Franziska Michor, Ph.D.
Scientific Investigator: Eric C. Holland, M.D., Ph.D.
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Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator: Denis Wirtz, Ph.D.
Scientific Investigator: Gregg L. Semenza, M.D., Ph.D.
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The Methodist Hospital Research Institute The Methodist Hospital Research Institute
Physical Sciences-Oncology Center
The Methodist Hospital Research Institute, Houston, TX

Principal Investigator: Mauro Ferrari, Ph.D.
Scientific Investigator: Steven A. Curley, M.D.
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Princeton University Princeton University
Physical Sciences-Oncology Center
Princeton University, Princeton, NJ

Principal Investigator: Robert H. Austin, Ph.D.
Scientific Investigator: Thea D. Tlsty, Ph.D.
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Stanford University Stanford University
Physical Sciences-Oncology Center
Stanford University, Palo Alto, CA

Principal Investigator: Jan Liphardt, Ph.D.
Scientific Investigator: Valerie M. Weaver, Ph.D.
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Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigator: Michael L. Shuler, Ph.D.
Scientific Investigator: Barbara L. Hempstead, M.D., Ph.D.
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H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigator: Robert A. Gatenby, M.D.
Scientific Investigator: Robert J. Gillies, Ph.D.
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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator: Scott Manalis, Ph.D.
Scientific Investigator: Tyler Jacks, Ph.D.
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Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigator: Thomas V. O'Halloran, Ph.D.
Scientific Investigator: Jonathan D. Licht, M.D.
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The Scripps Research Institute The Scripps Research Institute
Physical Sciences-Oncology Center
The Scripps Research Institute, La Jolla, CA

Principal Investigator: Peter Kuhn, Ph.D.
Scientific Investigator: Kelly J. Bethel, M.D.
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University Of Southern California University Of Southern California
Physical Sciences-Oncology Center
University of Southern California, Los Angeles, CA

Principal Investigator: W. Daniel Hillis, Ph.D.
Scientific Investigator: David B. Agus, M.D.
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