H. Lee Moffitt Cancer Center & Research Institute
H. Lee Moffitt Cancer Center & Research Institute Physical Sciences-Oncology Center's (MCC PS-OC) mission is to assemble a multi-disciplinary group of scientists to incorporate physical science concepts into cancer biology and oncology. Cancer progression can be categorized into several stages defined by markedly diverse temporal and spatial scales - carcinogenesis, invasive cancer, and clinical therapy. Each of these phases of cancer will be explored by this center. In particular, in the investigation of carcinogenesis, these investigators propose that both genetic alterations and microenvironmental selection pressures must be deciphered to impede somatic evolution. Furthermore, this group of prominent theoreticians, cancer biologists and clinicians will apply mathematical modeling to determine if oncogenesis is regulated by the escape from tissue homeostasis, a fresh perspective on the unfolding of cancer. These investigators have a long history of expertly drawing on mathematical modeling to shed light on a variety of complex biological problems in cancer and should provide further insight into the complex problems associated with cancer.